Safety of an inactivated SARS-CoV-2 vaccine among healthcare workers in China.

Background: Although the inactivated SARS-CoV-2 vaccine (CoronaVac) has undergone preclinical tests and clinical trials evaluating its efficacy and safety, few data have been reported in the post-licensure real-world setting. We aimed to assess the safety of the vaccine among healthcare workers.Methods: A self-administered online survey on monitoring adverse reactions post vaccination was conducted among the staff who worked at and were vaccinated in a tertiary hospital in Taizhou, China, from February 24 to 7 March 2021. A total of 1526 subjects responded to the questionnaire when they received an e-mail or an e-poster on WeChat.Results: The incidences of overall adverse reactions after the first and second injections were 15.6% (238/1526) and 14.6% (204/1397), respectively. The most common adverse reaction was localized pain at the injection site, with an incidence of 9.6% and 10.7% after each dose, accounting for 61.8% and 73.0% of adverse reactions, respectively. Fatigue, muscle pain, and headache were the most common systemic adverse reactions.Conclusions: These findings implied that the inactivated CoronaVac vaccine has an acceptable safety profile among healthcare workers due to the low incidence of self-reported adverse reactions. This may boost public confidence in nationwide mass vaccination campaigns.

[Correlation of delta18O in precipitation and moisture sources at Yunfu, Western Guangdong Province, China].

Fifty-nine samples of atmospheric precipitation were collected at Yunfu, Western Guangdong province during the period of April 5, 2005 to April 1, 2006 and their oxygen isotopic compositions were analyzed. Results show that delta18O values range from -12.47 per thousand to -0.18 per thousand with an average of -4.91 per thousand; the delta18O values of summer and autumn (from May to September) are relatively lower, ranging from -10.00 per thousand to -5.00 per thousand with an average of -6.30 per thousand; the delta18O values of winter and spring (from October to next April) are relatively higher, ranging from - 3.00 per thousand to - 1.00 per thousand with an average of - 2.20 per thousand. These delta18O values have relatively marked negative correlation with the corresponding temperatures and water vapour pressure and their coefficients are both -0.60; but they have had negative correlation with the precipitation amount, the coefficient is -0.33. Comparing with the monthly delta18O value of Guangzhou atmospheric precipitation, those of Yunfu City is relatively lower, maybe the reason is that Yunfu City is influenced by stronger South-West Asian Monsoon. The results of HYSPLIT back trajectory analysis indicated that the differences of delta18O values are determined by different water vapour sources during the pre-rainy season (from April to June), post-rainy season (from July to September) and non-rainy season (from October to next April), so the delta18O values can be considered as an indicator of denoting their water vapour sources, relatively higher delta18O values denote the water vapour sources are denaturalized tropical hot air mass located in the subtropical sea areas (including the South China Sea), western Pacific Ocean; relatively lower delta18O values indicate denaturalized tropical hot air mass from the India Ocean and Bengal Gulf.